Monocyte, macrophage and dendritic cell heterogeneity



Vincenzo Bronte, Israel Charo, Frédéric Geissmann (organisateur), Steffen Jung, Klaus Ley (organisateur), Gordon G. MacPherson, Alberto Mantovani, Markus Manz, Miriam Merad, Kristen Mueller (journaliste), Eric Pamer, Michael Sieweke, Ralph Steinman, Fil Swirski, Jo Van Ginderachter


Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.

Compte rendu

Ce séminaire a fait l’objet d’une publication dans la revue Science (Science 5 February 2010: Vol. 327. no. 5966, pp. 656 – 661 DOI: 10.1126/science.1178331). Pour accéder à l’article, merci d’utiliser les liens du magazine Science.

Further to this seminar, an article has been published in the magazine Science (Science 5 February 2010: Vol. 327. no. 5966, pp. 656 – 661 DOI: 10.1126/science.1178331). Please use the links proposed by Science magazine to get the abstract, the reprint or the full text.


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